Endocrine Abstracts

Background: It becomes increasingly evident that features of the metabolic syndrome are already present in young obese patients. Especially an impaired glucose metabolism with insulin resistance is an alarming sign of existing comorbidity of childhood obesity. Metformin has been argued as one pharmacological option to improve impaired glucose metabolism at least in obese adults. So far three prospective randomized studies were performed in childhood cohorts with <30 patien...

Few large-scale multicenter data on additional immune phenomena in patients with type-1 diabetes are available. The DPV initiative aggregates standardized anonymized patient records for quality control and epidemiologic research. This report includes data on 23 837 patients with type-1 diabetes, age <30 years and at least 1 antibody measurement, from 242 specialized centers from Germany and Austria (8012 patients <12 years, 12 866 12–18 years and 2959 patients 18&...